Active Clinical Trials at OOS

All Clinical Trials

ARTEMIDE-Lung02 (D702BC00001)

Tumor site:
Lung
Description:
A Phase III, Randomized, Double-blind, Multicenter, Global Study of Rilvegostomig or Pembrolizumab in Combination with Platinum-based Chemotherapy for the First-line Treatment of Patients with Metastatic Squamous Non-small Cell Lung Cancer Whose Tumors Express PD-L1
Available at:
Notes:
Sponsor: AstraZeneca; NCT Number: NCT06692738

ARTEMIDE-Lung03 (D702FC00001)

Tumor site:
Lung
Description:
A Phase III, Randomized, Double-blind, Multicenter, Global Study of Rilvegostomig or Pembrolizumab in Combination with Platinum-based Chemotherapy for the First-line Treatment of Patients with Metastatic Non-squamous Non-small Cell Lung Cancer Whose Tumors Express PD-L1
Available at:
Notes:
Sponsor: AstraZeneca; NCT Number: NCT06627647

ASTX030-01

Tumor site:
Hematologic (MDS, CMML, AML)
Description:
A Multi-phase, Dose-Escalation followed by an Open-label, Randomized, Crossover Study of Oral ASTX030 (Cedazuridine and Azacitidine Given in Combination) Versus Subcutaneous Azacitidine in Subjects with Myelodysplastic Syndromes (MDS), Chronic Myelomonocytic Leukemia (CMML), or Acute Myeloid Leukemia (AML)
Available at:
Notes:
Sponsor: Astex; NCT Number: NCT04256317

B Stronger I (01-PS-001)

Tumor site:
Breast
Description:
Breast Cancer-Minimal/Molecular Residual Disease Detection and Therapy Monitoring in Patients with Early Stage TNBC-Phase I (B-STRONGER-I)
Notes:
Sponsor: Personalis; NCT Number: NCT06230185

BillionToOne (NS-002)

Tumor site:
Solid Tumors
Description:
Tumor methylation scores will be quantified at baseline across all tumor types to establish the clinical limit of detection of the assay. Associations between baseline tumor methylation score and PFS, OS, and disease control rate will be examined across therapeutic regimens and cancer types to test the hypothesis that the TMS is prognostic of outcome.
Notes:
Study Sponsor: BillionToOne Inc.; IRB number: 20231272

Elegant (STML-ELA-0422)

Tumor site:
Breast
Description:
Elacestrant versus Standard Endocrine Therapy in Women and Men with Node-Positive, Estrogen Receptor-positive, HER2-negative, Early Breast Cancer with High Risk of Recurrence- A Global, Multicenter, Randomized, Open-Label Phase 3 study
Available at:
Notes:
Sponsor: Stenline Therapeutics, Inc.; NCT Number: NCT05563220

GEMINI

Tumor site:
Lung
Description:
TEMPUS GEMINI (TP-CA-002) NSCLC SURVEILLANCE STUDY: A Longitudinal Multi-Omic Biomarker Profiling Study of Patients with Non-Small Cell Lung Cancer (NSCLC)
Notes:
Sponsor: Tempus; IRB Number: NCT05236114

INTRINSIC

Tumor site:
Colorectal Cancer
Description:
A Phase I/Ib global, multicenter, open-label umbrella study evaluating the safety and efficacy of targeted therapies in subpopulations of patients with metastatic colorectal cancer
Available at:
Notes:
Sponsor: Roche; NCT Number: NCT04929223

Mirati KRYSTAL 7

Tumor site:
Lung (NSCLC)
Description:
Phase 3 Trial of MRTX849 Plus Pembrolizumab for NSCLC With KRAS G12C Mutation (KRYSTAL-7)
Available at:
Notes:
Sponsor: Mirati Therapeutics Inc; NCT Numer: NCT04613596

Ovation-23-001

Tumor site:
Breast; Lung
Description:
Collection of Biological Specimens and Associated Health Information for Secondary Research in Future Studies
Notes:
Ovation.io, Inc. NCT# NCT06369441
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